Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3
M. D. Martens, N. Seshadri, L. Nguyen, D. Chapman, E. S. Hensen, B. Xiang, L. Falk, A. Mendoza, S. Rattan, S. B. Gibson, R. Keijzer, A. D. Saleem, G. M. Hatch, C. A. Doucette, J. M. Karch, , J. W. Gordon
This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.
bioRxiv · Oct 9, 2020Cell Biology