Author

A. R. West

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Research Focus:metabolism & bioenergetics· 3 Organism:human· 2

Frequent Co-Authors

D. Chapman· 4 shared E. Turner-Brannen· 4 shared J. T. Field· 3 shared J. W. Gordon· 3 shared M. D. Martens· 3 shared A. Saleem· 2 shared C. Rampitsch· 2 shared G. M. Hatch· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCell Biology

D. Chapman

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype.

J. T. Field, D. Chapman, Y. Hai, S. Ghavami, A. R. West, B. Ozerklig, A. Saleem, J. Kline, A. A. Mendelson, J. Kindrachuk, B. Triggs-Raine, J. W. Gordon

This study shows Nix regulates muscle phenotype by coordinating mitophagy, ER-phagy, and nuclear calcium signaling, affecting insulin sensitivity and fiber-type composition.

bioRxiv · Mar 18, 2023 · PreprintCell Biology

Development of a 3D bioprinted airway smooth muscle model for manipulating structure and measuring contraction

J. O. Osagie, S. S. Syeda, E. Turner-Brannen, M. Guimond, L. C. Parrenas, A. Haroon, P. Imasuen, A. R. West

This paper develops a 3D bioprinted airway smooth muscle model that simulates different mechanical contexts in the lung and demonstrates its ability to measure contraction and respond to stimuli.

bioRxiv · Dec 15, 2022 · PreprintPhysiology

Skeletal muscle-derived extracellular vesicles are altered with chronic contractile activity: a dynamic light scattering analysis

P. O. Obi, E. Turner-Brannen, A. R. West, H. I. Labouta, J. Gordon, A. Saleem

This study shows chronic contractile activity reduces the size and zeta potential of skeletal muscle-derived extracellular vesicles using dynamic light scattering.

bioRxiv · Feb 25, 2022 · PreprintCell Biology

Oxidised phosphatidylcholines induce multiple functional defects in airway epithelial cells

C. D. Pascoe, N. Roy, E. Turner-Brannen, A. Schultz, J. Vaghasiya, A. Ravandi, A. J. Halayko, A. R. West

This study shows oxidized phosphatidylcholines (OxPC) impair airway epithelial cell function, causing barrier dysfunction, reduced proliferation, and oxidative stress, consistent with asthma pathology.

bioRxiv · Oct 26, 2020Cell Biology

Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3

M. D. Martens, N. Seshadri, L. Nguyen, D. Chapman, E. S. Hensen, B. Xiang, L. Falk, A. Mendoza, S. Rattan, S. B. Gibson, R. Keijzer, A. D. Saleem, G. M. Hatch, C. A. Doucette, J. M. Karch, , J. W. Gordon

This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.

bioRxiv · Oct 9, 2020Cell Biology

Misoprostol Attenuates Cardiomyocyte Proliferation in the Neonatal Heart Through Bnip3 and Perinuclear Calcium Signaling

M. D. Martens, J. T. Field, N. Seshadri, C. Day, D. Chapman, R. Keijzer, C. R. Doucette, G. M. Hatch, A. R. West, T. L. Ivanco, J. W. Gordon

This study shows misoprostol reduces neonatal cardiomyocyte proliferation via Bnip3 and calcium signaling, offering potential therapeutic benefits for neonatal heart conditions.

Journal of Molecular and Cellular Cardiology · Sep 1, 2020Peer-reviewedCell Biology

Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation.

S. C. da Silva Rosa, M. D. Martens, J. T. Field, L. Nguyen, S. Kereliuk, Y. Hai, D. Chapman, W. Diehl-Jones, M. Aliani, A. R. West, J. Thliveris, S. Ghavami, C. Rampitsch, V. W. Dolinsky, J. Gordon

The paper shows that Nix-induced mitochondrial fission, mitophagy, and insulin resistance in myocytes are reversed by PKA phosphorylation.

bioRxiv · Feb 20, 2020Cell Biology

Development of an in vitro Experimental Model for Investigating the Effect of Matrix Stiffness on Epithelial Barrier Permeability

N. Roy, E. Turner-Brannen, A. R. West

The paper develops an in vitro model to measure epithelial barrier permeability under varying substrate stiffness and shows that stiffness affects barrier function.

bioRxiv · Nov 1, 2019 · PreprintBioengineering