Author

J. W. Gordon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Chapman· 4 shared G. M. Hatch· 4 shared A. R. West· 3 shared J. T. Field· 3 shared M. D. Martens· 3 shared A. Saleem· 2 shared N. Seshadri· 2 shared R. Keijzer· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCell Biology

D. Chapman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype.

J. T. Field, D. Chapman, Y. Hai, S. Ghavami, A. R. West, B. Ozerklig, A. Saleem, J. Kline, A. A. Mendelson, J. Kindrachuk, B. Triggs-Raine, J. W. Gordon

This study shows Nix regulates muscle phenotype by coordinating mitophagy, ER-phagy, and nuclear calcium signaling, affecting insulin sensitivity and fiber-type composition.

bioRxiv · Mar 18, 2023 · PreprintCell Biology

Profiling skeletal muscle-derived secretome with differentiation and acute contractile activity

B. Bydak, T. M. Pierdona, S. Seif, K. Sidhom, P. O. Obi, H. I. Labouta, J. W. Gordon, A. Saleem

This study compares extracellular vesicles from skeletal muscle cells before and after differentiation, finding differences in size, protein yield, and marker expression, but no effect of acute contractile activity.

bioRxiv · Feb 20, 2022 · PreprintPhysiology

Tafazzin regulates the function of lipopolysaccharide activated B lymphocytes in mice

H. M. Zegallai, E. Abu-El-Rub, L. K. Cole, J. Field, E. M. Mejia, J. W. Gordon, A. J. Marshall, G. M. Hatch

This study shows that tafazzin deficiency impairs B cell function and metabolism in response to lipopolysaccharide in mice.

bioRxiv · May 17, 2021Immunology

Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3

M. D. Martens, N. Seshadri, L. Nguyen, D. Chapman, E. S. Hensen, B. Xiang, L. Falk, A. Mendoza, S. Rattan, S. B. Gibson, R. Keijzer, A. D. Saleem, G. M. Hatch, C. A. Doucette, J. M. Karch, , J. W. Gordon

This study shows misoprostol prevents hypoxia-induced cardiac dysfunction by phosphorylating Bnip3, altering its localization and reducing necroinflammation and mitochondrial damage.

bioRxiv · Oct 9, 2020Cell Biology

Misoprostol Attenuates Cardiomyocyte Proliferation in the Neonatal Heart Through Bnip3 and Perinuclear Calcium Signaling

M. D. Martens, J. T. Field, N. Seshadri, C. Day, D. Chapman, R. Keijzer, C. R. Doucette, G. M. Hatch, A. R. West, T. L. Ivanco, J. W. Gordon

This study shows misoprostol reduces neonatal cardiomyocyte proliferation via Bnip3 and calcium signaling, offering potential therapeutic benefits for neonatal heart conditions.

Journal of Molecular and Cellular Cardiology · Sep 1, 2020Peer-reviewedCell Biology

Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress.

J. T. Field, M. D. Martens, W. Mughal, Y. Hai, D. Chapman, G. M. Hatch, T. L. Ivanco, W. Diehl-Jones, J. W. Gordon

This study shows misoprostol reduces Bnip3 expression and promotes alternative splicing to protect cells from hypoxia-induced damage by regulating calcium homeostasis.

bioRxiv · May 2, 2018Cell Biology