S. T. Johnston

TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility

This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.

Avoidance, confusion or solitude? Modelling how noise pollution affects whale migration

This study develops a mathematical model to assess how ocean noise pollution affects whale migration by simulating communication, navigation, and noise propagation.

Intent matters: how flow & forms of information impact collective navigation

This study shows that collective navigation benefits depend on whether individuals share intended or actual headings, with intended headings providing robust advantages across various flows.

Free and interfacial boundaries in individual-based models of multicellular biological systems

This study investigates how different cell boundary descriptions affect population dynamics in individual-based models of multicellular systems, finding that Voronoi tessellation is most sensitive and overlapping spheres couples timescale to boundary description.

On predicting heterogeneity in nanoparticle dosage

This paper develops a stochastic model to predict nanoparticle dosage heterogeneity by accounting for biological processes like cell division and asymmetric inheritance.

Spatial-temporal analysis of nanoparticles in live tumor spheroids impacted by cell origin and density

This paper develops a platform to analyze nanoparticle uptake in 3D tumor spheroids, showing uptake inversely relates to particle size and varies with cell type and spheroid density.

Modelling collective navigation via nonlocal communication

This paper develops a mathematical model of collective navigation that incorporates uncertainty in cue interpretation and perception, showing improved efficiency in group navigation compared to individual navigation.

Unpacking the Allee effect: determining individual-level mechanisms that drive global population dynamics

The paper develops a stochastic individual-based model to link local mechanisms to global Allee effects in population dynamics, using ecological and cell biology data.

Isolating the sources of heterogeneity in nanoparticle-cell interactions

This paper presents a mathematical framework to isolate factors causing heterogeneity in nanoparticle-cell interactions and demonstrates three key factors explaining experimental variation.

A new and accurate continuum description of moving fronts

This paper introduces a new continuum description for moving fronts in population processes, accurately predicting population persistence or extinction across all parameter regimes.