Author

J. M. Ridlon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:metagenomics· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

H. L. Doden· 4 shared P. G. Wolf· 4 shared K. Anantharaman· 3 shared E. S. Cowley· 2 shared H. R. Gaskins· 2 shared I. Cann· 2 shared L. Ly· 2 shared R. Gaskins· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

H. L. Doden

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes

J. W. L. Lee, E. S. Cowley, P. G. Wolf, H. L. Doden, T. Murai, K. Y. O. Caicedo, L. Ly, F. Sun, H. Takei, H. Nittono, S. L. Daniel, I. Cann, R. Gaskins, K. Anantharaman, J. M. Ridlon

This paper identifies novel enzymes from gut Firmicutes that convert 'kinked' primary bile acids into 'flat' secondary bile acids, with increased abundance in colorectal cancer patients.

bioRxiv · Aug 9, 2022Biochemistry

Diversity and distribution of sulfur metabolism in the human gut microbiome and its association with colorectal cancer

P. G. Wolf, E. S. Cowley, A. Breister, S. Matatov, L. Lucio, P. Polak, J. M. Ridlon, H. R. Gaskins, K. Anantharaman

The paper examines sulfur metabolism in the human gut microbiome, finding it more diverse and associated with colorectal cancer.

bioRxiv · Jul 1, 2021 · PreprintMicrobiology

Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine

J. Wen, G. Padilla Mercado, A. Volland, H. L. Doden, C. R. Lickwar, T. Crooks, G. Kakiyama, C. Kelly, J. L. Cocchiaro, J. M. Ridlon, J. F. Rawls

This study investigates Fxr signaling and microbial bile salt metabolism in zebrafish intestines, revealing conserved pathways and Fxr roles in transcriptional programs.

bioRxiv · Dec 13, 2020Physiology

Completion of the gut microbial epi-bile acid pathway

H. L. Doden, J. M. P. Alves, J. M. Ridlon, P. G. Wolf, H. R. Gaskins, K. Anantharaman

The paper identifies the gene encoding 12{beta}-HSDH, completes the epi-bile acid pathway, and shows its prevalence in the human gut microbiome.

bioRxiv · Sep 27, 2020Microbiology

Infection with novel Bacteroides phage BV01 alters host transcriptome and bile acid metabolism in a common human gut microbe

D. E. Campbell, L. Ly, J. M. Ridlon, A. Hsiao, R. Whitaker, P. H. Degnan

This paper shows that infection with Bacteroides phage BV01 alters host transcriptome and bile acid metabolism in B. vulgatus, with effects dependent on tspO gene disruption.

Cell Reports · Sep 1, 2020Peer-reviewedMicrobiology

Gut bacteria convert cortisol into a distinct hostsignalling molecule

M. Freiberg, T. Wang, R. S. d. L. Rosa, A. Osswald, M. C. R. Melo, D. G. Stouffer, P. S. Buobu, C. Welsh, L. Yang, A. M. Abdel-Hamid, H. L. Doden, S. Devendran, R. M. Pollet, S. Goldberg, L. Ray, , J. M. Ridlon

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.

bioRxiv · Jun 12, 2020 · PreprintMicrobiology