Author

I. Cann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

J. M. Ridlon· 3 shared S. L. Daniel· 3 shared C. Greening· 2 shared H. L. Doden· 2 shared K. Anantharaman· 2 shared K. Y. O. Caicedo· 2 shared P. B. Hylemon· 2 shared P. G. Wolf· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMicrobiology

J. M. Ridlon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An expanded metabolic pathway for androgen production by host-associated bacteria

T. Wang, S. Ahmad, A. Cruz-Lebron, S. E. Ernst, K. Y. O. Caicedo, Y. Jeong, B. Binion, P. Mbuvi, D. Dutta, F. V. Fernandez-Materan, A. M. Breister, J. W. Lee, J. D. Kang, S. C. Harris, S. Ikegawa, , J. M. Ridlon

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.

bioRxiv · Jun 9, 2024 · PreprintMicrobiology

Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes

J. W. L. Lee, E. S. Cowley, P. G. Wolf, H. L. Doden, T. Murai, K. Y. O. Caicedo, L. Ly, F. Sun, H. Takei, H. Nittono, S. L. Daniel, I. Cann, R. Gaskins, K. Anantharaman, J. M. Ridlon

This paper identifies novel enzymes from gut Firmicutes that convert 'kinked' primary bile acids into 'flat' secondary bile acids, with increased abundance in colorectal cancer patients.

bioRxiv · Aug 9, 2022Biochemistry

Gut bacteria convert cortisol into a distinct hostsignalling molecule

M. Freiberg, T. Wang, R. S. d. L. Rosa, A. Osswald, M. C. R. Melo, D. G. Stouffer, P. S. Buobu, C. Welsh, L. Yang, A. M. Abdel-Hamid, H. L. Doden, S. Devendran, R. M. Pollet, S. Goldberg, L. Ray, , J. M. Ridlon

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.

bioRxiv · Jun 12, 2020 · PreprintMicrobiology

Alternative hydrogen uptake pathways suppress methane production in ruminants

C. Greening, R. Geier, C. Wang, L. C. Woods, S. E. Morales, M. J. McDonald, R. Rushton-Green, X. C. Morgan, S. Koike, S. C. Leahy, W. J. Kelly, I. Cann, G. T. Attwood, G. M. Cook, R. I. Mackie

This study identifies alternative hydrogen uptake pathways in ruminants that reduce methane production by competing with methanogens for hydrogen.

bioRxiv · Dec 4, 2018 · PreprintMicrobiology