R. Gaskins

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance

This study shows CHCHD2 promotes glioblastoma cell proliferation, hypoxia-induced invasion, and drug resistance by affecting mitochondrial function and nuclear signaling.

Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes

This paper identifies novel enzymes from gut Firmicutes that convert 'kinked' primary bile acids into 'flat' secondary bile acids, with increased abundance in colorectal cancer patients.

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model

This study shows that microglia reduce glioblastoma invasion in a 3D hydrogel model through paracrine signaling, identified via secretome and transcriptome analysis.

Gut bacteria convert cortisol into a distinct hostsignalling molecule

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.