Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
K. J. Condon, J. M. Orozco, C. H. Adelmann, J. B. Spinelli, P. W. van der Helm, J. M. Roberts, T. Kunchok, D. M. Sabatini
This study uses CRISPR screens to identify genes regulating mTORC1 activity and reveals that mitochondrial dysfunction is sensed through AMPK and HRI signaling pathways.
bioRxiv · Oct 22, 2020Cell Biology