Author

J. M. Orozco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

T. Kunchok· 2 shared A. L. Cangelosi· 1 shared C. A. Lewis· 1 shared C. H. Adelmann· 1 shared D. M. Sabatini· 1 shared D. Sabatini· 1 shared J. B. Spinelli· 1 shared J. M. Roberts· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

T. Kunchok

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2 papers

Recent·Most cited

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

K. J. Condon, J. M. Orozco, C. H. Adelmann, J. B. Spinelli, P. W. van der Helm, J. M. Roberts, T. Kunchok, D. M. Sabatini

This study uses CRISPR screens to identify genes regulating mTORC1 activity and reveals that mitochondrial dysfunction is sensed through AMPK and HRI signaling pathways.

bioRxiv · Oct 22, 2020Cell Biology

Dihydroxyacetone phosphate signals glucose availability to mTORC1

J. M. Orozco, P. A. Krawczyk, S. M. Scaria, A. L. Cangelosi, S. H. Chan, T. Kunchok, C. A. Lewis, D. Sabatini

This study identifies dihydroxyacetone phosphate (DHAP) as the glucose-derived metabolite that activates mTORC1, linking glucose availability to cell growth regulation.

bioRxiv · Jun 21, 2020Cell Biology