Author

J. B. Spinelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. A. Godbole· 1 shared A. Clermont· 1 shared A. Dean· 1 shared A. K. Walker· 1 shared A. L. Munden· 1 shared C. A. Lewis· 1 shared C. H. Adelmann· 1 shared C. S. Fraser· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCell Biology

A. A. Godbole

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Author profile →

4 papers

Recent·Most cited

p53 controls choice between apoptotic and non-apoptotic death following DNA damage

M. E. Honeywell, M. S. Isidor, N. W. Harper, R. E. Fontana, P. Cruz-Gordillo, S. A. Porto, C. S. Fraser, K. A. Sarosiek, D. A. Guertin, J. B. Spinelli, M. J. Lee

This study shows p53 regulates whether DNA damage triggers apoptosis or non-apoptotic death, revealing that p53-deficient cells die via MPT-driven necrosis due to high basal respiration.

bioRxiv · Jan 17, 2023 · PreprintCell Biology

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

A. A. Godbole, S. Gopalan, T.-K. Nguyen, A. L. Munden, P. Vo, C. A. Lewis, J. B. Spinelli, T. G. Fazzio, A. K. Walker

The paper identifies distinct roles of SAMS-1 and SAMS-4 in regulating H3K4me3 and gene expression during heat stress in C. elegans.

bioRxiv · Mar 30, 2022Cell Biology

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

K. J. Condon, J. M. Orozco, C. H. Adelmann, J. B. Spinelli, P. W. van der Helm, J. M. Roberts, T. Kunchok, D. M. Sabatini

This study uses CRISPR screens to identify genes regulating mTORC1 activity and reveals that mitochondrial dysfunction is sensed through AMPK and HRI signaling pathways.

bioRxiv · Oct 22, 2020Cell Biology

PHD3 controls energy homeostasis and exercise capacity.

H. Yoon, J. B. Spinelli, E. Zaganjor, S. J. Wong, N. J. German, E. C. Randall, A. Dean, A. Clermont, J. J. Paulo, D. Garcia, H. Li, N. Y. R. Agar, L. J. Goodyear, R. J. Shaw, S. P. Gygi, , M. C. Haigis

The paper was submitted in error and the authors do not wish it to be cited.

bioRxiv · Sep 29, 2019 · PreprintCell Biology