Author

D. M. Sabatini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:drug response / drug discovery· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

C. H. Adelmann· 2 shared G. A. Wyant· 2 shared H. R. Keys· 2 shared M. Abu-Remaileh· 2 shared M. E. Pacold· 2 shared T. Kunchok· 2 shared A. Ali· 1 shared A. Friedman· 1 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

C. H. Adelmann

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10 papers

Recent·Most cited

Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

Y. Yu, S. M. Gao, Y. Guan, P. Hu, Q. Zhang, J. Liu, B. Jing, Q. Zhao, D. M. Sabatini, M. Abu-Remaileh, S. Y. Jung, M. C. Wang

This study uses proteomic profiling to reveal lysosomal heterogeneity and its role in longevity by identifying protein dynamics and interactions in lysosomes.

eLife · Jan 19, 2024Peer-reviewedCell Biology

An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway

G. Y. Liu, P. Jouandin, R. E. Bahng, N. Perrimon, D. M. Sabatini

The paper identifies a nutrient sensor in Drosophila that integrates into the mTORC1 pathway to respond to methionine availability, revealing an evolutionary mechanism for expanding nutrient sensing capabilities.

bioRxiv · May 25, 2023Cell Biology

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

J. M. Winter, H. L. Fresenius, H. R. Keys, C. N. Cunningham, J. Ryan, D. Sirohi, J. A. Berg, S. R. Tripp, P. Barta, N. Agarwal, A. Letai, D. M. Sabatini, M. L. Wohlever, J. Rutter

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

bioRxiv · Jul 1, 2021 · PreprintCancer Biology

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

K. J. Condon, J. M. Orozco, C. H. Adelmann, J. B. Spinelli, P. W. van der Helm, J. M. Roberts, T. Kunchok, D. M. Sabatini

This study uses CRISPR screens to identify genes regulating mTORC1 activity and reveals that mitochondrial dysfunction is sensed through AMPK and HRI signaling pathways.

bioRxiv · Oct 22, 2020Cell Biology

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

N. J. Rossiter, K. S. Huggler, C. H. Adelmann, H. R. Keys, R. W. Soens, D. M. Sabatini, J. R. Cantor

This study uses CRISPR screens in different media to identify conditionally essential genes in human cells, showing how medium composition affects gene essentiality.

bioRxiv · Aug 31, 2020Cancer Biology

MCART1 is required for mitochondrial NAD transport

N. Kory, J. uit de Bos, S. van der Rijt, N. Jankovic, M. Guera, N. Arp, I. A. Pena, G. Prakash, S. H. Chan, T. Kunchok, C. A. Lewis, D. M. Sabatini

The paper identifies MCART1 as a mitochondrial NAD+ transporter in human cells by showing its essentiality with ETC components and its effect on NAD levels and mitochondrial function.

bioRxiv · Aug 28, 2020 · PreprintCell Biology

A PEROXO-Tag enables rapid isolation of peroxisomes from human cells

G. J. Ray, E. A. Boydston, E. Shortt, G. A. Wyant, S. Lourido, W. W. Chen, D. M. Sabatini

This paper introduces a PEROXO-Tag and PEROXO-IP workflow for rapid and specific isolation of human peroxisomes, validated through proteomic profiling.

iScience · May 1, 2020Peer-reviewedCell Biology

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

B. Ngo, E. Kim, V. Osorio-Vasquez, S. Doll, S. Bustraan, A. Luengo, S. M. Davidson, A. Ali, G. D. Ferraro, D. Kang, J. Ni, R. Liang, A. Plasger, E. R. Kastenhuber, R. Eskandari, , M. E. Pacold

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

bioRxiv · Mar 3, 2020 · PreprintCancer Biology

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

J. M. Rohde, K. R. Brimacombe, L. Liu, M. E. Pacold, A. Yasgar, D. M. Cheff, T. D. Lee, G. Rai, B. Baljinnyam, Z. Li, A. Simeonov, M. D. Hall, M. Shen, D. M. Sabatini, M. B. Boxer

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.

Bioorganic & Medicinal Chemistry · May 1, 2018Peer-reviewedCancer Biology

Identification and characterization of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

E. K. O'Shea, Z. Yu, L. E. Surface, C. Y. Park, M. A. Horlbeck, G. A. Wyant, M. Abu-Remaileh, T. R. Peterson, D. M. Sabatini, J. S. Weissman

The paper identifies SLC37A3 as a transporter required for nitrogen-containing bisphosphonates (N-BPs) to enter the cytosol, revealing their mechanism of action.

bioRxiv · Mar 27, 2018Biochemistry