J. M. Valpuesta

This study identifies an N-terminal motif in α-synuclein oligomers that drives fibril conversion and shows how a mutation disrupts this process, offering a new therapeutic target.

This study uses cryo-electron microscopy to determine the structure of T7 bacteriophage core proteins involved in DNA translocation across the bacterial envelope.

This study identifies mitochondrial cytochrome c as a factor that releases ARF tumor suppressor from NPM sequestration in the nucleolus upon DNA damage.

This paper identifies a 28-amino-acid region in Arc critical for oligomerization and virus-like capsid formation, showing that exogenous RNA enhances assembly.

The paper determines the structure of a BBSome subcomplex and shows how a mutation disrupts its assembly, linking it to Bardet-Biedl syndrome.