S. Ventura

Structural insights into the human P2X1 receptor and ligand interactions

This study determines the structure of the human P2X1 receptor in different ligand-bound states and identifies key residues involved in ligand binding and selectivity.

Antidiabetic Drugs May Prevent Kidney Damage

This study shows canagliflozin prevents kidney damage from ischemia and reperfusion in non-diabetic rats by improving renal function and reducing oxidative stress.

A targetable N-terminal motif orchestrates α-synuclein oligomer to fibril conversion

This study identifies an N-terminal motif in α-synuclein oligomers that drives fibril conversion and shows how a mutation disrupts this process, offering a new therapeutic target.

Mass Mortality of Marine Mammals Associated to Highly Pathogenic Influenza Virus (H5N1) in South America

The paper reports a mass mortality event of over 3,000 sea lions in Peru linked to H5N1 influenza virus, suggesting possible transmission from infected wild birds.

Cryo-EM Structure of a Mammalian-specific Alternative Amyloid Exon

The paper presents the cryo-EM structure of hnRNPDL-2 amyloid fibrils, showing how alternative splicing controls RNP assembly through an amyloid exon.

Rational optimization of a transcription factor activation domain inhibitor

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

Spliceosomic dysregulation unveils NOVA1 as an actionable therapeutic target in pancreatic neuroendocrine tumors

The paper identifies NOVA1 as a therapeutic target in PanNETs by showing its role in splicing dysregulation, cell proliferation, and drug resistance.

α-Helical peptidic scaffolds to target α-synuclein pathogenic species with high affinity and selectivity.

The paper identifies α-helical peptides that selectively bind and neutralize pathogenic α-synuclein species with high affinity, suggesting potential therapeutic and diagnostic applications.