Author

J. M. Virta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

H. R. Vickery· 2 shared M. R. Arkin· 2 shared C. Ottmann· 1 shared D. A. Brow· 1 shared D. N. Kenanova· 1 shared E. J. Montemayor· 1 shared E. J. Visser· 1 shared E. Sijbesma· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

H. R. Vickery

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

H. R. Vickery, J. M. Virta, M. Konstantinidou, M. R. Arkin

The paper develops a NanoBRET assay to evaluate molecular glues targeting 14-3-3σ client proteins in living cells, showing EC50 values consistent with in vitro measurements.

bioRxiv · Dec 31, 2023Cell Biology

A Systematic Approach to the Discovery of Protein-Protein Inter-action Stabilizers

D. N. Kenanova, E. J. Visser, J. M. Virta, E. Sijbesma, F. Centorrino, H. R. Vickery, M. Zhong, J. R. Neitz, L. Brunsveld, C. Ottmann, M. R. Arkin

This study uses disulfide tethering to identify small molecule stabilizers of 14-3-3{sigma} phospho-peptide interactions, finding selective and efficacious fragments for four of five client complexes.

bioRxiv · Jan 29, 2023 · PreprintBiochemistry

Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes

E. J. Montemayor, J. M. Virta, S. M. Hayes, Y. Nomura, D. A. Brow, S. E. Butcher

This study identifies the molecular mechanisms by which Lsm1-7 and Lsm2-8 complexes bind RNA with distinct specificity, revealing structural determinants for their unique functions.

bioRxiv · Apr 22, 2020Biochemistry