M. Zhong

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

RFX6 at locus 6q22 confers metastasis and drug resistance in prostate cancer

This study identifies RFX6 at locus 6q22 as a driver of prostate cancer metastasis and drug resistance through epigenetic and genetic mechanisms.

A comparison of convolutional neural networks and few-shot learning in classifying long-tailed distributed tropical bird songs

This study compares CNN and few-shot learning methods for classifying rare tropical bird songs, finding Siamese Networks perform better with limited data.

A Systematic Approach to the Discovery of Protein-Protein Inter-action Stabilizers

This study uses disulfide tethering to identify small molecule stabilizers of 14-3-3{sigma} phospho-peptide interactions, finding selective and efficacious fragments for four of five client complexes.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating PPARγ-UCP2 cascade

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

A Safe and Effective Mucosal RSV Vaccine Consisting of RSV Phosphoprotein and Flagellin Variant

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity

This study shows that multi-session delivery of rTMS paired with sensory stimulation induces long-term plasticity in the rat primary somatosensory cortex, while single sessions or sensory stimulation alone do not.

LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization

The paper identifies Dnmt3aos as a lncRNA regulating Dnmt3a expression and DNA methylation in macrophage polarization, revealing its role in modulating IFN-gamma expression.

MLL-AF9 Initiates Transformation From Fast-Proliferating Myeloid Progenitors

This study shows that fast-cycling granulocyte-macrophage progenitors are more likely to transform into leukemia when expressing the MLL-AF9 oncogene.