Mitohormesis reprograms macrophage metabolism to enforce tolerance
G. A. Timblin, K. M. Tharp, B. Ford, J. M. Winchester, J. Wang, S. Zhu, R. I. Khan, S. K. Louie, A. T. Iavarone, J. ten Hoeve, D. K. Nomura, A. Stahl, K. Saijo
This paper shows that mitochondrial stress from mtROS and mtRES triggers mitohormesis in macrophages, leading to tolerance by suppressing proinflammatory gene transcription.
bioRxiv · Oct 20, 2020Immunology