Author

K. M. Tharp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Ford· 2 shared D. K. Nomura· 2 shared G. A. Timblin· 2 shared H. Shao· 2 shared J. Wang· 2 shared K. Saijo· 2 shared V. M. Weaver· 2 shared A. Alcala· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

B. Ford

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.

M. Oorloff, A. Hruby, M. Averbukh, A. Alcala, N. Dutta, T. Castro Torres, D. Moaddeli, M. Vega, J. Kim, A. Bong, A. J. Coakley, D. Hicks, J. Wang, T. Wang, S. Hoang, , R. Sanabria

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

bioRxiv · Apr 11, 2024Cell Biology

Coenzyme A governs proinflammatory macrophage metabolism

G. A. Timblin, K. M. Tharp, J. t. Hoeve, D. S. Kantner, I. Baydemir, E. A. Noel, C. Khantwal, P. K. Singh, J. N. Farahzad, J. Dominguez-Andres, R. E. Vance, N. W. Snyder, V. M. Weaver

This study shows that exogenous CoA enhances TLR-driven proinflammatory and antimicrobial responses in macrophages by promoting oxidative metabolism and histone acetylation.

bioRxiv · Aug 30, 2022 · PreprintImmunology

Mitohormesis reprograms macrophage metabolism to enforce tolerance

G. A. Timblin, K. M. Tharp, B. Ford, J. M. Winchester, J. Wang, S. Zhu, R. I. Khan, S. K. Louie, A. T. Iavarone, J. ten Hoeve, D. K. Nomura, A. Stahl, K. Saijo

This paper shows that mitochondrial stress from mtROS and mtRES triggers mitohormesis in macrophages, leading to tolerance by suppressing proinflammatory gene transcription.

bioRxiv · Oct 20, 2020Immunology

Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma

I. D. Ferguson, Y.-H. T. Lin, C. Lam, H. Shao, M. Hale, K. M. Tharp, M. C. Mariano, V. Steri, D. Wang, P. Phojanokong, S. T. Tuomivaara, B. Hann, C. Driessen, B. V. Ness, J. E. Gestwicki, A. P. Wiita

This study identifies allosteric HSP70 inhibitors that overcome proteasome inhibitor resistance in multiple myeloma by targeting mitochondrial HSPA9 and disrupting mitoribosome stability.

bioRxiv · Apr 21, 2020Cancer Biology

Adhesion-mediated mechanosignaling forces mitohormesis

K. M. Tharp, R. Higuchi-Sanabria, G. Timblin, B. Ford, C. Garzon-Coral, C. Schneider, J. M. Muncie, C. Stashko, J. Daniele, A. S. Moore, P. Frankino, S. Manoli, H. Shao, A. L. Richards, K.-H. Chen, , V. M. Weaver

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

bioRxiv · Mar 6, 2020Cell Biology