Author

J. ten Hoeve

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. A. Martins· 1 shared A. F. Camargo· 1 shared A. M. Gillespie· 1 shared A. Stahl· 1 shared A. T. Iavarone· 1 shared B. Ford· 1 shared C. Taglang· 1 shared D. G. Pinheiro· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

A. A. Martins

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Telomerase reverse transcriptase induces targetable alterations in glutathione and nucleotide biosynthesis in glioblastomas

S. Udutha, C. Taglang, G. Batsios, A. M. Gillespie, M. Tran, S. M. Ronen, J. ten Hoeve, T. G. Graeber, P. Viswanath

This study identifies metabolic vulnerabilities in glioblastomas driven by TERT and shows that combining GCLC and glutamine-utilizing enzyme inhibitors synergistically targets these vulnerabilities.

bioRxiv · Nov 14, 2023 · PreprintCancer Biology

In vivo CRISPRi screen reveals the differential requirement for mitochondrial respiratory chain function between in vivo and in vitro tumor growth

H. Nakaoka, N. Bennett, R. Okimoto, D. Laurent, Y. Sei, T. Bivona, J. ten Hoeve, T. Graeber, K. Nakamura, J. Nakamura

The paper uses CRISPRi to show that mitochondrial respiratory chain genes are critical for in vivo tumor growth but not for metastasis in lung cancer xenografts.

bioRxiv · Oct 3, 2021 · PreprintCancer Biology

Systemic impact of the expression of the mitochondrial alternative oxidase on Drosophila development

A. F. Camargo, S. Saari, G. S. Garcia, M. M. Chioda, M. F. Othonicar, A. A. Martins, G. Hayashi, J. ten Hoeve, H. T. Jacobs, D. G. Pinheiro, E. Dufour, M. T. Oliveira

This study investigates the systemic effects of expressing the mitochondrial alternative oxidase AOX in Drosophila, revealing metabolic and developmental disruptions under low-nutrient conditions.

bioRxiv · Sep 24, 2021 · PreprintBiochemistry

Mitohormesis reprograms macrophage metabolism to enforce tolerance

G. A. Timblin, K. M. Tharp, B. Ford, J. M. Winchester, J. Wang, S. Zhu, R. I. Khan, S. K. Louie, A. T. Iavarone, J. ten Hoeve, D. K. Nomura, A. Stahl, K. Saijo

This paper shows that mitochondrial stress from mtROS and mtRES triggers mitohormesis in macrophages, leading to tolerance by suppressing proinflammatory gene transcription.

bioRxiv · Oct 20, 2020Immunology