Author

J. Mallon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:imaging· 1 Organism:multiple species· 1

Frequent Co-Authors

D. Singh· 3 shared S. Bailey· 3 shared T. Ha· 3 shared Y. Wang· 3 shared A. Poddar· 2 shared O. Yang· 2 shared A. Bisson· 1 shared A. Lammers· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

D. Singh

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Salactin, a dynamically unstable actin homolog in Haloarchaea

J. Zheng, A. Lammers, J. Mallon, T. Litschel, E. Moody, D. A. R. Diaz, A. Schmid, T. A. Williams, A. Bisson, E. C. Garner

This study identifies and characterizes Salactin, an actin homolog in Haloarchaea, showing it forms dynamically unstable filaments and is involved in chromosomal segregation under low-ploidy conditions.

bioRxiv · Mar 9, 2023Microbiology

Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding

I. Okafor, D. Singh, Y. Wang, M. Jung, H. Wang, J. Mallon, S. Bailey, J. K. Lee, T. Ha

The paper evaluates how non-canonical guide RNAs and Cas9 variants affect DNA unwinding, finding that some combinations reduce off-target activity while maintaining on-target efficiency.

bioRxiv · May 20, 2019Biophysics

Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1

D. Singh, J. Mallon, A. Poddar, Y. Wang, R. Tipanna, O. Yang, S. Bailey, T. Ha

This study characterizes the DNA interrogation and product release kinetics of three Cpf1 orthologues using single-molecule fluorescence and biochemical assays, revealing differences from Cas9 in binding and cleavage requirements.

bioRxiv · Apr 9, 2018Biophysics

Mechanisms of improved specificity of engineered Cas9s revealed by single molecule analysis

D. Singh, Y. Wang, J. Mallon, O. Yang, J. Fei, A. Poddar, D. Ceylan, S. Bailey, T. Ha

This study reveals how engineered Cas9 variants improve specificity by altering DNA unwinding dynamics and cleavage rates in response to mismatches.

bioRxiv · Sep 22, 2017Biophysics