Author

I. Okafor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

J. K. Lee· 2 shared T. Ha· 2 shared D. Singh· 1 shared H. H. Kim· 1 shared H. Wang· 1 shared J. Choi· 1 shared J. Lee· 1 shared J. Mallon· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

J. K. Lee

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2 papers

Recent·Most cited

Sniper2L, a high-fidelity Cas9 variant with high activity

Y.-h. Kim, N. Kim, I. Okafor, S. Choi, S. Min, J. Lee, K. Choi, J. Choi, V. Harihar, Y. Kim, J.-S. Kim, J. K. Lee, T. Ha, H. H. Kim

This paper develops Sniper2L, a high-fidelity Cas9 variant with improved specificity and retained high on-target activity, and introduces a deep-learning model to predict its activity.

bioRxiv · Dec 5, 2022Bioengineering

Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding

I. Okafor, D. Singh, Y. Wang, M. Jung, H. Wang, J. Mallon, S. Bailey, J. K. Lee, T. Ha

The paper evaluates how non-canonical guide RNAs and Cas9 variants affect DNA unwinding, finding that some combinations reduce off-target activity while maintaining on-target efficiency.

bioRxiv · May 20, 2019Biophysics