Gasdermin B over-expression arbitrates HER2-targeted therapy resistance by inducing protective autophagy
M. Gamez-Chiachio, A. Molina-Crespo, C. Ramos-Nebot, J. Martinez-Val, L. Martinez, K. Gassner, F. J. Llobet, C. Gonzalo-Consuegra, M. Cordani, C. Bernado-Morales, E. Diaz, A. Rojo-Sebastian, J. C. Trivino, L. Sanchez, R. Rodriguez-Barrueco, , G. Moreno-Bueno
This study identifies GSDMB over-expression as a driver of HER2-targeted therapy resistance through autophagy induction and shows that combining lapatinib with chloroquine enhances therapeutic efficacy in GSDMB-positive tumors.
Journal of Experimental & Clinical Cancer Research · Sep 26, 2022Peer-reviewedCancer Biology