J. Mendoza

Structural basis of S-adenosylmethionine-dependent Allosteric Transition from Active to Inactive States in Methylenetetrahydrofolate Reductase

The paper reports crystal structures of cMTHFR in active and inhibited states, revealing structural changes and AdoMet binding, and investigates phosphorylation sites in hMTHFR.

Development of a sensor for disulfide bond formation in diverse bacteria

The paper develops a biosensor to detect disulfide bond inhibition in gram-negative bacteria, enabling the study of oxidative protein folding and identification of inhibitors against multidrug-resistant pathogens.

Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo

This study determines the first high-resolution structure of full-length cobalamin-dependent methionine synthase and captures cobalamin loading, revealing insights into its dynamic domain rearrangements.

SbCYP79A61 Produces Phenylacetaldoxime, a Precursor of Benzyl Cyanide and Phenylacetic Acid in Sorghum bicolor

This study identifies SbCYP79A61 as an enzyme in sorghum that produces phenylacetaldoxime and shows benzyl cyanide as an intermediate in its biosynthesis pathway.

The OPAQUE1/DISCORDIA2 myosin XI is required for phragmoplast guidance during asymmetric cell division in maize

This study identifies OPAQUE1 as essential for phragmoplast guidance during asymmetric cell division in maize, showing it interacts with kinesins to ensure proper cytokinesis.

Comparative regulomics reveals pervasive selection on gene dosage following whole genome duplication

The paper uses comparative phylogenetic analysis of transcriptomic data to show pervasive expression evolution in ohnologs following salmonid WGD, driven by regulatory divergence and gene dosage shifts.

Enhancement of drought tolerance on guinea grass by dry alginate macrobeads as inoculant of Bacillus strains

This study evaluates dry alginate macrobeads as an inoculant for Bacillus strains to enhance drought tolerance in Guinea grass, showing improved growth and physiological parameters with co-inoculation.

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

This paper shows that type I and III interferons induce interferon stimulated genes with different kinetics, and these differences are intrinsic to the signaling pathways, not receptor abundance.