T. Höfer

Quantitative analysis of MHC class II peptide exchange reveals pivotal role of peptide association rate

The paper develops a kinetic model to explain variation in HLA-DM susceptibility of MHC-II peptides and identifies two mechanisms shaping antigen presentation.

Temporal control of the integrated stress response by a stochastic molecular switch

The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.

Adaptation to host cell environment during experimental evolution of Zika virus

This study identifies genetic adaptations in Zika virus during experimental evolution in host cells, revealing increased infectivity and resistance to TLR3-induced restriction.

CycleFlow quantifies cell-cycle heterogeneity in vivo

CycleFlow quantifies cell-cycle heterogeneity by combining EdU incorporation and DNA content measurements with Bayesian inference.

Exponential Growth of Glioblastoma In Vivo Driven by Rapidly Dividing and Outwardly Migrating Cancer Stem Cells

This study identifies that glioblastoma grows exponentially due to symmetric divisions of brain tumor stem cells (BTSCs) accumulating at the tumor rim.

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

This paper shows that type I and III interferons induce interferon stimulated genes with different kinetics, and these differences are intrinsic to the signaling pathways, not receptor abundance.