c-Src-dependent phosphorylation of Mfn2 regulates endoplasmic reticulum-mitochondria tethering
P. Zhang, K. Ford, J. H. Sung, Y. Suzuki, M. Landherr, J. Moeller, I. Chaput, I. Polina, M. Kelly, B. Nieto, T. Tachibana, Y. Kusakari, M. W. Cypress, K. Drenkova, S. M. Adaniya, , J. O-Uchi
The paper shows that c-Src-dependent phosphorylation of Mfn2 reduces ER-mitochondria distance and enhances Ca2+ transfer, affecting ROS and mitochondrial bioenergetics.
bioRxiv · Feb 21, 2022 · PreprintCell Biology