Y. Suzuki

Meis1 isoform diversity orchestrates neural progenitor differentiation by regulating ATOH1 degradation at distinct subcellular compartments

The paper identifies functionally antagonistic Meis1 isoforms that regulate ATOH1 degradation through distinct subcellular localization and E3 ligase interactions, affecting neural progenitor differentiation.

Protein design of two-component tubular assemblies like cytoskeletons

This paper introduces NIPAD, a method to design two-component tubular protein assemblies that mimic biological structures like actin and microtubules, showing dynamic flexibility and reversible assembly.

Characterization of sediment and granite hosted deep underground research laboratories reveals diverse microbiome functions, limited temporal variation and substantial genomic conservation

The paper characterizes microbiomes in underground research labs, finding genomic conservation and similar functional profiles despite environmental differences.

The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules and transports double-stranded DNA

This study shows that Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA, reclassifying it as a processive and dimeric motor.

Dengue virus exploits the host tRNA epitranscriptome to promote viral replication

This study shows dengue virus exploits host tRNA modifications to enhance viral replication by altering translation of pro-viral proteins.

Synaptic plasticity in the medial preoptic area of male mice encodes social experiences with female and regulates behavior toward young

This study identifies synaptic plasticity in the medial preoptic area of male mice as critical for shifting from aggressive to paternal behavior after mating and interaction with pups.

Native spike flexibility revealed by BSL3 Cryo-ET of active SARS-CoV-2 virions

This study uses cryo-ET to analyze native, active SARS-CoV-2 virions, revealing a transient open-trimer prefusion state and hidden spike flexibility with implications for vaccine design.

Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patients

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

Characterization of an EG.5.1 clinical isolate in vitro and in vivo

This study characterizes the in vitro and in vivo properties of the EG.5.1 SARS-CoV-2 variant, showing increased transmissibility and altered antigenicity compared to XBB.1.5.

Selective elimination of CD169+ macrophages in lymph nodes invaded by breast cancers

This study shows metastasized breast cancer cells eliminate CD169+ macrophages from lymph nodes, impairing anti-cancer immunity.

Genome-resolved meta-omics unveils rock-hosted lifestyle of enigmatic DPANN archaea

This study investigates the lifestyle of DPANN archaea in rock-hosted environments using genome-resolved meta-omics, revealing a symbiotic lifestyle and ecological interactions with bacteria and minerals.

Wolbachia-induced inhibition of O'nyong nyong virus in Anopheles mosquitoes is mediated by Toll signaling and modulated by cholesterol

This study shows Wolbachia inhibits Onyong nyong virus in Anopheles mosquitoes via Toll signaling, but cholesterol suppresses this effect by modulating Toll signaling.

Extensive Copy Number Variation Explains Genome Size Variation in the Unicellular Zygnematophycean Alga, Closterium peracerosum-strigosum-littorale Complex

This study identifies genome size variation in the alga Closterium psl. complex as primarily due to copy number variation, with nonrandom distribution of CNV across gene functions.

Kaposis sarcoma-associated herpesvirus ORF67.5 functions as a component of the terminase complex

This study identifies ORF67.5 as a critical component of the KSHV terminase complex, essential for TR cleavage, capsid formation, and virus production.

Discovery of prevalent natural Wolbachia in Aedes aegypti in Metropolitan Manila, Philippines using locally designed primers: bacterial density is influenced by strain and host sex

The paper screens for Wolbachia density in Aedes aegypti from Metropolitan Manila using locally designed primers, finding higher densities in males and a unique strain wAegML with lower density than other strains.

Scale space calibrates present and subsequent spatial learning in Barnes maze in mice

This study shows that spatial learning in mice is influenced by the scale of the Barnes maze, with larger scale spaces requiring more computational resources and prior learning in larger scales facilitating subsequent learning in smaller scales.

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections

This study compares immune responses between primates and bats using single-cell RNA sequencing, revealing differences in antiviral gene induction and monocyte subsets.

Antiviral effect of candies containing persimmon-derived tannin against SARS-CoV-2 delta strain

This study shows that candies with persimmon-derived tannin reduce SARS-CoV-2 delta variant titers in saliva from healthy volunteers and patients with COVID-19.

Murine breast cancers disorganize the liver transcriptome in zonated manners

This study uses spatial transcriptomics to show that breast cancers disrupt liver zonation patterns, affecting specific metabolic and immune pathways in a zonated manner.

Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel Achilles heel for therapeutic intervention

This study uses cryo-EM to analyze wild-type and oncogenic KIT mutants, revealing structural changes and a potential therapeutic target in cancer.

Use of the particle agglutination/particle agglutination-inhibition test for antigenic analysis of SARS-CoV-2

This study develops a PA/PAI test to rapidly assess SARS-CoV-2 antigenicity using hACE2-bound latex beads, showing it can detect antigenic differences between variants.

The contribution of Kaposis sarcoma-associated herpesvirus ORF7 and its zinc-finger motif to viral genome cleavage and capsid formation

This study investigates the role of KSHV ORF7 and its zinc-finger motif in viral genome cleavage and capsid formation, revealing that ORF7 acts after ORF17 and is essential for proper capsid assembly and virion production.

Algorithmic design of 3D wireframe RNA polyhedra

The paper introduces an algorithmic design process and software pipeline for creating 3D wireframe RNA polyhedra, validated through experimental characterization of three structures.

Single-nucleotide substitution determines pollen production in Japanese cedar

This study identifies a single-nucleotide substitution in the TKPR1 gene that determines pollen production in Japanese cedar and suggests its potential application in creating pollen-free plants.

c-Src-dependent phosphorylation of Mfn2 regulates endoplasmic reticulum-mitochondria tethering

The paper shows that c-Src-dependent phosphorylation of Mfn2 reduces ER-mitochondria distance and enhances Ca2+ transfer, affecting ROS and mitochondrial bioenergetics.

Conifer leaves have a peroxisomal oxidative decarboxylation path in the photorespiratory pathway

The study shows conifer peroxisomes are not a major site for catalase and reveal a unique oxidative decarboxylation path in photorespiration.

Fe(III)-dependent anaerobic methane-oxidizing activity in a deep underground borehole demonstrated by in-situ pressure groundwater incubation

The study demonstrates Fe(III)-dependent anaerobic methane oxidation in deep groundwater using in-situ pressure incubation, showing higher activity in 214-m deep samples compared to 249-m deep samples.

Single mutation makes Escherichia coli an insect mutualist

The paper shows that a single mutation in E. coli enables it to become an insect mutualist by disrupting carbon catabolite repression.

NeoRdRp: A comprehensive dataset for identifying RNA-dependent RNA polymerase of various RNA viruses from metatranscriptomic data

The paper introduces NeoRdRp, a dataset of RNA-dependent RNA polymerase (RdRp) HMM profiles for identifying RNA viruses from metatranscriptomic data, showing improved detection compared to existing methods.

Dynamics of peripheral blood flow across sleep stages

This study compares pulse rate variability (PRV) and heart rate variability (HRV) across sleep stages using peripheral blood flow measurements, finding PRV provides similar information to HRV and may offer additional insights.