Author

J. O-Uchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:electrophysiology· 1

Frequent Co-Authors

B. S. Jhun· 3 shared B. Nieto· 2 shared I. Chaput· 2 shared I. Polina· 2 shared J. Mishra· 2 shared M. Landherr· 2 shared M. W. Cypress· 2 shared P. Zhang· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

B. S. Jhun

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3 papers

Recent·Most cited

Mitochondrial Ca2+ uniporter (MCU) variants form plasma-membrane channels

I. Polina, J. Mishra, M. W. Cypress, M. Landherr, N. Valkov, I. Chaput, B. Nieto, U. Mende, P. Zhang, B. S. Jhun, J. O-Uchi

The paper identifies a novel MCU variant, MCU-S, which forms Ca2+-permeable plasma-membrane channels, expanding the known function of MCU beyond mitochondrial Ca2+ uptake.

Communications Biology · May 20, 2026Peer-reviewedCell Biology

Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules in Two Rodent Models of Pulmonary Arterial Hypertension

F. Kazmirczak, L. Hartweck, N. T. Vogel, J. B. Mendelson, J. Park, R. M. Raveendran, J. O-Uchi, B. S. Jhun, S. Prisco, K. Prins

This study shows intermittent fasting activates AMPK in rodent PAH models, improving RV lipid metabolism, mitochondrial function, and microtubule structure.

bioRxiv · Mar 7, 2022Biochemistry

c-Src-dependent phosphorylation of Mfn2 regulates endoplasmic reticulum-mitochondria tethering

P. Zhang, K. Ford, J. H. Sung, Y. Suzuki, M. Landherr, J. Moeller, I. Chaput, I. Polina, M. Kelly, B. Nieto, T. Tachibana, Y. Kusakari, M. W. Cypress, K. Drenkova, S. M. Adaniya, , J. O-Uchi

The paper shows that c-Src-dependent phosphorylation of Mfn2 reduces ER-mitochondria distance and enhances Ca2+ transfer, affecting ROS and mitochondrial bioenergetics.

bioRxiv · Feb 21, 2022 · PreprintCell Biology