Raf promotes dimerization of the Ras G-domain with increased allosteric connections
M. Packer, J. A. Parker, J. K. Chung, Z. Li, Y. K. Lee, T. Cookis, H. Guterres, S. Alvarez, M. A. Hossain, D. P. Donnelly, J. N. Agar, L. Makowski, M. Buck, J. T. Groves, C. Mattos
This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.
Proceedings of the National Academy of Sciences · Mar 9, 2021Peer-reviewedBiophysics