Author

J. N. Leonard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

R. E. Mitrut· 3 shared D. M. Stranford· 2 shared N. Kamat· 2 shared T. F. Gunnels· 2 shared A. N. Prybutok· 1 shared B. N. DiBiase· 1 shared B. Zhang· 1 shared C. S. Harper· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBioengineering

R. E. Mitrut

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

HaloTag display enables quantitative single-particle characterization and functionalization of engineered extracellular vesicles

R. E. Mitrut, D. M. Stranford, B. N. DiBiase, J. M. Chan, M. D. Bailey, M. Luo, C. S. Harper, T. J. Meade, M. Wang, J. N. Leonard

The paper develops a HaloTag-based system for quantitatively characterizing engineered proteins on extracellular vesicles and compares it to antibody labeling.

bioRxiv · Sep 25, 2023 · PreprintBioengineering

Comparative evaluation of synthetic cytokines for enhancing production and performance of NK92 cell-based therapies

S. Deol, P. S. Donahue, R. E. Mitrut, I. J. Hammitt-Kess, J. Ahn, B. Zhang, J. N. Leonard

The paper evaluates synthetic cytokines to enhance NK92 cell production and performance, finding that membrane-bound cytokines improve cytotoxicity and expansion.

bioRxiv · May 13, 2023Bioengineering

Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions

J. A. Peruzzi, T. F. Gunnels, H. I. Edelstein, P. Lu, D. Baker, J. N. Leonard, N. Kamat

This study shows how engineering protein-lipid interactions can improve the loading and delivery of protein cargo into extracellular vesicles for therapeutic applications.

bioRxiv · Apr 29, 2023 · PreprintBioengineering

Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cells

D. Stranford, L. M. Simons, K. Berman, L. Cheng, J. B. Lucks, J. F. Hultquist, J. N. Leonard

This paper develops methods to engineer extracellular vesicles for targeted delivery of biologics to T cells, demonstrating efficient cargo delivery using Cas9-sgRNA complexes.

bioRxiv · May 14, 2022Bioengineering

Mapping CAR T-cell design space using agent-based models

A. N. Prybutok, J. S. Yu, J. N. Leonard, N. Bagheri

The paper uses agent-based models to explore how CAR T-cell design parameters affect treatment outcomes in solid tumors.

bioRxiv · Apr 7, 2022Bioengineering

Elucidating design principles for engineering cell-derived vesicles to inhibit SARS-CoV-2 infection

T. F. Gunnels, D. M. Stranford, R. E. Mitrut, N. Kamat, J. N. Leonard

This study evaluates cell-derived vesicles as decoy nanoparticles to inhibit SARS-CoV-2 infection, finding they are effective against multiple variants and manufacturing methods.

bioRxiv · Dec 4, 2021Bioengineering