Author

J. S. Yu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Hao· 2 shared O. Reizes· 2 shared A. N. Prybutok· 1 shared A. W. Smith· 1 shared D. Bayik· 1 shared D. Chau· 1 shared D. J. Silver· 1 shared E. Esakov· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

J. Hao

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

K. Kay, J. Lee, E. S. Hong, J. Beilis, S. Dayal, E. R. Wesley, S. Mitchell, S. Z. Wang, D. J. Silver, J. Volovetz, S. Johnson, M. McGraw, M. M. Grabowski, T. Lu, L. Freytag, , J. Lathia

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

bioRxiv · Nov 14, 2023Cancer Biology

Mapping CAR T-cell design space using agent-based models

A. N. Prybutok, J. S. Yu, J. N. Leonard, N. Bagheri

The paper uses agent-based models to explore how CAR T-cell design parameters affect treatment outcomes in solid tumors.

bioRxiv · Apr 7, 2022Bioengineering

HAUSP Stabilizes SOX2 through Deubiquitination to Maintain Self-renewal and Tumorigenic Potential of Glioma Stem Cells

Z. Huang, K. Zhai, Q. Wu, X. Fang, Q. Huang, W. Tao, J. D. Lathia, J. S. Yu, J. N. Rich, S. Bao

This study identifies HAUSP as a deubiquitinase that stabilizes SOX2 in glioma stem cells, maintaining their self-renewal and tumorigenic potential, and shows that targeting HAUSP can enhance GBM treatment.

bioRxiv · Jun 9, 2021 · PreprintCancer Biology

A Novel Non-Invasive Epithelial Ovarian Cancer Mouse Model Of Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Z. Alali, M. P. Horowitz, D. Chau, L. Trestan, J. Hao, P. Qi, E. Esakov, R. L. DeBernardo, J. S. Yu, O. Reizes

This paper introduces a novel non-invasive mouse model of HIPEC to study its efficacy in epithelial ovarian cancer.

bioRxiv · May 16, 2021 · PreprintCancer Biology

Resolving the Interactions Between Class 3 Semaphorin Receptors in Live Cells

S. M. Christie, J. Hao, E. Tracy, M. Buck, J. S. Yu, A. W. Smith

This study uses PIE-FCCS to analyze receptor interactions in live cells, finding that Plexin D1 is monomeric while others form dimers or heteromers, with ligand-induced complex formation only observed for Plexin D1 and neuropilin-1.

bioRxiv · Feb 18, 2021 · PreprintBiophysics