Author

J. Noorbakhsh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. Brown· 1 shared A. Fultineer· 1 shared A. Saadat· 1 shared D. E. Root· 1 shared I. Boyle· 1 shared J. Chuang· 1 shared J. Dempster· 1 shared J. G. Doench· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Brown

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2 papers

Recent·Most cited

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

S. A. Misek, A. Fultineer, J. Kalfon, J. Noorbakhsh, I. Boyle, J. Dempster, L. Petronio, K. Huang, A. Saadat, T. Green, A. Brown, J. G. Doench, D. E. Root, J. McFarland, R. Beroukhim, J. S. Boehm

The paper identifies ancestry-related biases in CRISPR experiments caused by germline variants, showing disproportionate effects in cell models from recent African descent.

Nature Communications · Jun 7, 2024Peer-reviewedCancer Biology

Uncertainties In Tumor Allele Frequencies Limit Power To Infer Evolutionary Pressures

J. Noorbakhsh, J. Chuang

The paper critiques the use of high R2 values to infer tumor evolutionary pressures, arguing that they may not uniquely support neutral evolution.

bioRxiv · May 4, 2017Cancer Biology