Author

J. Dempster

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:CRISPR screen· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:human· 2 Research Focus:imputation· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

G. McConnell· 3 shared C. G. Hansen· 2 shared D. E. Root· 2 shared J. G. Doench· 2 shared J. S. Boehm· 2 shared S. Foylan· 2 shared W. B. Amos· 2 shared A. Asfaw· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

G. McConnell

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Author profile →

5 papers

Recent·Most cited

Standing wave mesoscopy

S. Foylan, J. K. Schniete, L. S. Koelln, J. Dempster, C. G. Hansen, M. Shaw, T. J. Bushell, G. McConnell

This paper introduces a mesoscale version of standing wave microscopy, enabling high-resolution imaging of large cell populations in fixed and living specimens under flow conditions.

bioRxiv · Mar 8, 2023 · PreprintCell Biology

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

S. A. Misek, A. Fultineer, J. Kalfon, J. Noorbakhsh, I. Boyle, J. Dempster, L. Petronio, K. Huang, A. Saadat, T. Green, A. Brown, J. G. Doench, D. E. Root, J. McFarland, R. Beroukhim, J. S. Boehm

The paper identifies ancestry-related biases in CRISPR experiments caused by germline variants, showing disproportionate effects in cell models from recent African descent.

bioRxiv · Nov 18, 2022Cancer Biology

MesoTIRF: a Total Internal Reflection Fluorescence illuminator for axial super-resolution membrane imaging at the mesoscale

S. Foylan, W. B. Amos, J. Dempster, L. S. Kölln, C. G. Hansen, M. J. Shaw, G. McConnell

The paper introduces MesoTIRF, a TIRF illuminator that expands the field of view while maintaining high resolution for membrane imaging.

bioRxiv · Aug 19, 2022 · PreprintBiophysics

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

D. P. Bondeson, B. R. Paolella, A. Asfaw, M. Rothberg, T. Skipper, C. Langan, A. Gonzalez, L. Surface, K. Ito, M. Kazachkova, W. N. Colgan, A. Warren, J. Dempster, J. M. Krill-Burger, M. Ericcson, , T. R. Golub

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

bioRxiv · Oct 16, 2020Cancer Biology

Fast Optical Sectioning for Widefield Fluorescence Mesoscopy with the Mesolens based on HiLo Microscopy

J. Schniete, A. Franssen, J. Dempster, T. Bushell, W. B. Amos, G. McConnell

The paper introduces a fast optical sectioning method for widefield fluorescence mesoscopy using HiLo microscopy, achieving subcellular resolution and speeds up to 30 times faster than confocal laser scanning microscopy.

bioRxiv · Jul 23, 2018Biophysics