Author

J. McFarland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Scientific Communication & Education· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

F. Vazquez· 2 shared J. S. Boehm· 2 shared T. Golub· 2 shared A. Apffel· 1 shared A. Brown· 1 shared A. D'Andrea· 1 shared A. Fultineer· 1 shared A. Gonzalez· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

F. Vazquez

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Author profile →

5 papers

Recent·Most cited

The Free Association Sessions: Perspectives on a Novel Teaching Platform by Final Year Medical Students and Basic Specialist Trainees in Psychiatry.

J. McFarland, G. Brar, P. Hayes, M. E. Abdalla

The paper evaluates a structured reflective practice program for medical students and trainees, finding it fosters a comfortable environment and enhances appreciation for complexity in psychiatry.

bioRxiv · Nov 21, 2022Scientific Communication & Education

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

S. A. Misek, A. Fultineer, J. Kalfon, J. Noorbakhsh, I. Boyle, J. Dempster, L. Petronio, K. Huang, A. Saadat, T. Green, A. Brown, J. G. Doench, D. E. Root, J. McFarland, R. Beroukhim, J. S. Boehm

The paper identifies ancestry-related biases in CRISPR experiments caused by germline variants, showing disproportionate effects in cell models from recent African descent.

bioRxiv · Nov 18, 2022Cancer Biology

Evaluation of Postgraduate Educational Environment of Doctors Training in Psychiatry: a mixed method study

M. Elzain, L. Moran, G. McCarth, S. Hyde, J. McFarland

This study evaluates the educational environment for psychiatry postgraduate training in Ireland using mixed methods, finding a generally positive environment with areas needing improvement.

bioRxiv · Feb 24, 2022 · PreprintScientific Communication & Education

Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics

J. M. Dempster, J. Krill-Burger, A. Warren, J. McFarland, J. S. Boehm, F. Vazquez, W. Hahn, T. Golub, A. Tsherniak

This study compares DNA- and expression-based models for predicting cancer cell viability and finds expression models are more accurate and interpretable.

bioRxiv · Feb 21, 2020 · PreprintCancer Biology

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

E. Chan, T. Shibue, J. McFarland, B. Gaeta, J. McPartlan, M. Ghandi, J. B. Liu, J.-B. Lazaro, N. Dumont, A. Gonzalez, A. Apffel, S. O. Ali, L. Leung, E. Roberts, E. Rizvochenko, , A. J. Bass

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.

bioRxiv · Dec 21, 2018Cancer Biology