Author

J. O. Gardner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. J. Hryckowian· 3 shared J. L. Sonnenburg· 3 shared W. Van Treuren· 2 shared A. T. Fisher· 1 shared B. D. Merrill· 1 shared B. Schumann· 1 shared C. Bertozzi· 1 shared C. Martin· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

A. J. Hryckowian

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3 papers

Recent·Most cited

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates

D. Pensinger, A. T. Fisher, H. A. Dobrila, W. Van Treuren, J. O. Gardner, S. K. Higginbottom, M. M. Carter, B. Schumann, C. Bertozzi, V. Anikst, C. Martin, E. Robilotti, J. Chow, R. H. Buck, L. S. Tompkins, , A. J. Hryckowian

This study shows butyrate reduces C. difficile fitness in mice and humans, and inhibits growth of diverse C. difficile isolates, suggesting dietary interventions could help prevent CDI.

bioRxiv · May 20, 2022Microbiology

Multiple phase-variable mechanisms, including capsular polysaccharides, modify bacteriophage susceptibility in Bacteroides thetaiotaomicron

N. T. Porter, A. J. Hryckowian, B. D. Merrill, J. J. Fuentes, J. O. Gardner, R. W. P. Glowacki, S. Singh, R. D. Crawford, E. S. Snitkin, J. L. Sonnenburg, E. C. Martens

This study shows that capsular polysaccharides and other phase-variable cell surface structures in Bacteroides thetaiotaomicron influence bacteriophage susceptibility, enabling bacterial persistence through phase variation.

bioRxiv · Mar 26, 2020 · PreprintMicrobiology

Microbiota Accessible Carbohydrates Suppress Clostridium difficile in a Murine Model

A. J. Hryckowian, W. Van Treuren, S. A. Smits, N. M. Davis, J. O. Gardner, D. M. Bouley, J. L. Sonnenburg

The paper shows that microbiota accessible carbohydrates (MACs) reduce Clostridium difficile infection in mice by suppressing bacterial burdens.

bioRxiv · Feb 17, 2018Microbiology