Author

W. Van Treuren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:human· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:metagenomics· 4 Assay:metabolomics· 3 Research Focus:differential expression· 2

Frequent Co-Authors

J. L. Sonnenburg· 6 shared A. J. Hryckowian· 3 shared D. Dodd· 3 shared S. K. Higginbottom· 3 shared B. D. Merrill· 2 shared J. O. Gardner· 2 shared J. Sonnenburg· 2 shared L. Guthrie· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersMicrobiology

J. L. Sonnenburg

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10 papers

Recent·Most cited

Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.

K. M. Ng, S. Pannu, S. Liu, J. C. Burckhardt, T. Hughes, W. Van Treuren, J. Nguyen, K. Naqvi, B. Nguyen, C. A. Clayton, D. M. Pepin, S. R. Collins, C. Tropini

This study predicts microbiota responses to environmental pH and osmolality by analyzing bacterial growth under controlled conditions and identifying predictive genes and pathways.

bioRxiv · Aug 31, 2022Microbiology

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates

D. Pensinger, A. T. Fisher, H. A. Dobrila, W. Van Treuren, J. O. Gardner, S. K. Higginbottom, M. M. Carter, B. Schumann, C. Bertozzi, V. Anikst, C. Martin, E. Robilotti, J. Chow, R. H. Buck, L. S. Tompkins, , A. J. Hryckowian

This study shows butyrate reduces C. difficile fitness in mice and humans, and inhibits growth of diverse C. difficile isolates, suggesting dietary interventions could help prevent CDI.

bioRxiv · May 20, 2022Microbiology

Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes

L. Guthrie, S. Spencer, D. Perelman, W. Van Treuren, S. Han, F. B. Yu, E. Sonnenburg, M. A. Fischbach, T. W. Meyer, J. Sonnenburg

A 7-day homogeneous diet did not reduce interindividual variation in uremic microbiome-derived metabolites, indicating limited dietary impact and suggesting the need for microbial interventions.

bioRxiv · Oct 29, 2021Microbiology

A metabolomics pipeline enables mechanistic interrogation of the gut microbiome

S. Han, W. Van Treuren, C. R. Fischer, B. D. Merrill, B. C. DeFelice, J. M. Sanchez, S. K. Higginbottom, L. Guthrie, L. A. Fall, D. Dodd, M. A. Fischbach, J. L. Sonnenburg

The paper develops a metabolomics pipeline to identify microbiota-dependent metabolites and explores their links to host phenotypes using machine learning and comparative genomics.

bioRxiv · May 25, 2021Microbiology

Bacteroides thetaiotaomicron-infecting bacteriophage isolates inform sequence-based host range prediction

A. J. Hryckowian, B. D. Merrill, N. T. Porter, W. Van Treuren, E. J. Nelson, R. A. Garlena, D. A. Russell, E. C. Martens, J. L. Sonnenburg

The paper isolates and analyzes 27 bacteriophages infecting Bacteroides thetaiotaomicron, identifies phage structural gene alleles linked to infectivity, and highlights unexplored phage diversity in the human gut.

bioRxiv · Mar 4, 2020Microbiology

Electron transfer proteins in gut bacteria yield metabolites that circulate in the host

Y. Liu, H. Chen, W. Van Treuren, B.-H. Hou, S. K. Higginbottom, J. L. Sonnenburg, D. Dodd

The paper shows that gut bacteria use reductive amino acid metabolism to produce metabolites that circulate in the host, linked to energy capture via the Rnf complex.

bioRxiv · Dec 11, 2019 · PreprintMicrobiology

Depletion of microbiome-derived molecules in the host using Clostridium genetics

C.-J. Guo, B. Allen, K. Hiam, D. Dodd, W. van Treuren, S. Higginbottom, C. Fischer, J. Sonnenburg, M. Spitzer, M. Fischbach

This study develops a genetic method to disable Clostridium species and investigates the impact of microbiome-derived molecules on host IgA modulation.

bioRxiv · Aug 27, 2018Microbiology

Live imaging of Aiptasia larvae, a model system for studying coral bleaching, using a simple microfluidic device

W. Van Treuren, K. Brower, L. Labanieh, D. Hunt, S. Lensch, B. Cruz, H. N. Cartwright, C. Tran, P. M. Fordyce

This paper introduces a microfluidic device to image live Aiptasia larvae and their algal symbionts under environmental stress, observing algal expulsion as a potential mechanism of coral bleaching.

bioRxiv · Jul 19, 2018Ecology

Links between environment, diet, and the hunter-gatherer microbiome

G. K. Fragiadakis, S. A. Smits, E. D. Sonnenburg, W. Van Treuren, G. Reid, R. Knight, A. Manjurano, J. Changalucha, M. G. Dominguez-Bello, J. Leach, J. L. Sonnenburg

The paper examines the microbiome of Hadza hunter-gatherers, finding seasonal changes and unique bacterial families compared to industrialized populations.

bioRxiv · May 15, 2018Microbiology

Microbiota Accessible Carbohydrates Suppress Clostridium difficile in a Murine Model

A. J. Hryckowian, W. Van Treuren, S. A. Smits, N. M. Davis, J. O. Gardner, D. M. Bouley, J. L. Sonnenburg

The paper shows that microbiota accessible carbohydrates (MACs) reduce Clostridium difficile infection in mice by suppressing bacterial burdens.

bioRxiv · Feb 17, 2018Microbiology