Author

A. J. Hryckowian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 9

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:human· 6 Organism:mouse· 5 Assay:metagenomics· 4 Research Focus:ecology & biodiversity· 2 Research Focus:gene regulatory network inference· 2 Organism:rat· 2

Frequent Co-Authors

J. L. Sonnenburg· 5 shared B. D. Merrill· 3 shared J. O. Gardner· 3 shared W. Van Treuren· 3 shared D. Pensinger· 2 shared E. C. Martens· 2 shared E. J. Nelson· 2 shared H. A. Dobrila· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMicrobiology

J. L. Sonnenburg

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Exogenous butyrate inhibits butyrogenic metabolism and alters expression of virulence genes in Clostridioides difficile

D. Pensinger, H. A. Dobrila, D. M. Stevenson, N. M. Davis, D. Amador-Noguez, A. J. Hryckowian

This study shows exogenous butyrate inhibits C. difficile growth by interfering with its own butyrate production and alters virulence gene expression.

bioRxiv · Jul 6, 2023 · PreprintMicrobiology

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates

D. Pensinger, A. T. Fisher, H. A. Dobrila, W. Van Treuren, J. O. Gardner, S. K. Higginbottom, M. M. Carter, B. Schumann, C. Bertozzi, V. Anikst, C. Martin, E. Robilotti, J. Chow, R. H. Buck, L. S. Tompkins, , A. J. Hryckowian

This study shows butyrate reduces C. difficile fitness in mice and humans, and inhibits growth of diverse C. difficile isolates, suggesting dietary interventions could help prevent CDI.

bioRxiv · May 20, 2022Microbiology

Independent host- and bacterium-based determinants protect a model symbiosis from phage predation

J. B. Lynch, B. D. Bennett, B. D. Merrill, E. G. Ruby, A. J. Hryckowian

The paper identifies host- and bacterium-based mechanisms that protect a symbiotic relationship from phage predation.

bioRxiv · Jul 9, 2021Microbiology

Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis

A. N. Shkoporov, E. V. Khokhlova, N. Stephens, C. Hueston, S. Seymour, A. J. Hryckowian, D. Scholz, R. P. Ross, C. Hill

The paper shows that phase variation in Bacteroides intestinalis capsular polysaccharides enables long-term phage persistence through dynamic resistance and delayed lysis mechanisms.

bioRxiv · Dec 2, 2020Microbiology

Multiple phase-variable mechanisms, including capsular polysaccharides, modify bacteriophage susceptibility in Bacteroides thetaiotaomicron

N. T. Porter, A. J. Hryckowian, B. D. Merrill, J. J. Fuentes, J. O. Gardner, R. W. P. Glowacki, S. Singh, R. D. Crawford, E. S. Snitkin, J. L. Sonnenburg, E. C. Martens

This study shows that capsular polysaccharides and other phase-variable cell surface structures in Bacteroides thetaiotaomicron influence bacteriophage susceptibility, enabling bacterial persistence through phase variation.

bioRxiv · Mar 26, 2020 · PreprintMicrobiology

Bacteroides thetaiotaomicron-infecting bacteriophage isolates inform sequence-based host range prediction

A. J. Hryckowian, B. D. Merrill, N. T. Porter, W. Van Treuren, E. J. Nelson, R. A. Garlena, D. A. Russell, E. C. Martens, J. L. Sonnenburg

The paper isolates and analyzes 27 bacteriophages infecting Bacteroides thetaiotaomicron, identifies phage structural gene alleles linked to infectivity, and highlights unexplored phage diversity in the human gut.

bioRxiv · Mar 4, 2020Microbiology

Gold-standard diagnostics are tarnished by lytic bacteriophage

E. J. Nelson, J. A. Grembi, D. L. Chao, J. R. Andrews, L. Alexandrova, P. H. Rodriguez, V. V. Ramachandran, M. A. Sayeed, J. Wamala, A. K. Debes, D. A. Sack, A. J. Hryckowian, F. Haque, S. Khatun, M. M. Rahman, , G. K. Schoolnik

This study shows that lytic bacteriophage and antibiotic exposure reduce diagnostic positivity for cholera, suggesting that current diagnostic methods may underestimate cholera burden.

bioRxiv · Jan 30, 2020 · PreprintMicrobiology

The clinical drug candidate ebselen attenuates inflammation and promotes microbiome recovery after antibiotic treatment for Clostridium difficile infection

M. Garland, A. J. Hryckowian, M. Tholen, S. Loscher, W. W. Van Treuren, K. Oresic Bender, J. L. Sonnenburg, M. Bogyo

This study shows ebselen reduces CDI recurrence and colitis in hamsters and promotes microbiome recovery without altering diversity in mice.

bioRxiv · Nov 1, 2019Microbiology

Microbiota Accessible Carbohydrates Suppress Clostridium difficile in a Murine Model

A. J. Hryckowian, W. Van Treuren, S. A. Smits, N. M. Davis, J. O. Gardner, D. M. Bouley, J. L. Sonnenburg

The paper shows that microbiota accessible carbohydrates (MACs) reduce Clostridium difficile infection in mice by suppressing bacterial burdens.

bioRxiv · Feb 17, 2018Microbiology