Author

J. O. Trent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:protein structure prediction· 3 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Chaires· 3 shared R. D. Gray· 3 shared J. B. Chaires· 2 shared L. W. DeLeeuw· 2 shared R. C. Monsen· 2 shared W. L. Dean· 2 shared D. Matulis· 1 shared L. Baranauskiene· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

J. Chaires

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

POT1 Stability and Binding Measured by Fluorescence Thermal Shift Assays

L. W. DeLeeuw, R. C. Monsen, V. Petrauskas, R. D. Gray, L. Baranauskiene, D. Matulis, J. O. Trent, J. Chaires

This paper describes two fluorescent thermal shift assays to quantify POT1 stability and DNA interactions, revealing mechanisms of POT1 inhibition.

bioRxiv · Jan 1, 2021Biophysics

The solution structures of higher-order human telomere G-quadruplex multimers

R. C. Monsen, S. Chakravarthy, W. L. Dean, J. B. Chaires, J. O. Trent

The paper determines the solution structures of higher-order human telomere G-quadruplex multimers using structural biology methods and finds they are semi-flexible with mixed G4 conformers and potential drug targeting sites.

bioRxiv · Nov 13, 2020Biophysics

Human POT1 Unfolds G-Quadruplexes by Conformational Selection

J. B. Chaires, R. D. Gray, W. L. Dean, R. Monson, L. W. DeLeeuw, V. Stribinskis, J. O. Trent

This paper investigates how POT1 unfolds human telomeric G-quadruplexes through a conformational selection mechanism, supported by kinetic, thermodynamic, and computational data.

bioRxiv · Jul 2, 2019Biophysics

Folding landscape of a parallel G-quadruplex

R. D. Gray, J. O. Trent, S. Arumugam, J. Chaires

The paper investigates the folding pathway of a G-quadruplex using spectroscopic and computational methods, revealing multiple intermediates and a slow unfolding process.

The Journal of Physical Chemistry Letters · Mar 7, 2019Peer-reviewedBiophysics

G-quadruplex secondary structure from circular dichroism spectroscopy

R. del Villar-Guerra, J. O. Trent, J. Chaires

This study builds a reference library of G-quadruplex CD spectra and develops an algorithm to estimate their secondary structure content using PCA and SVD.

bioRxiv · Sep 4, 2017Biophysics