S. Chakravarthy

SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations

This study uses biophysical and computational methods to characterize the structure of human Cdt1, revealing 'folded over' conformations that suggest a scaffold function.

Structure and mechanism of LARGE1 matriglycan polymerase

The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.

Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis

This study presents the structures of LbpB from Neisseria species in complex with lactoferrin, revealing its dual role in iron acquisition and immune evasion.

TWO CLASSES OF MYOSIN INHIBITORS, BLEBBISTATIN AND MAVACAMTEN, STABILIZE β-CARDIAC MYOSIN IN DIFFERENT STRUCTURAL AND FUNCTIONAL STATES

This study compares how two myosin inhibitors, mavacamten and blebbistatin, stabilize myosin in distinct structural and functional states, potentially affecting cardiac function differently.

The solution structures of higher-order human telomere G-quadruplex multimers

The paper determines the solution structures of higher-order human telomere G-quadruplex multimers using structural biology methods and finds they are semi-flexible with mixed G4 conformers and potential drug targeting sites.

Competitive exclusion of uropathogenic E. coli biofilm by Salmonella through matrix inhibition

The paper shows that Salmonella inhibits uropathogenic E. coli biofilm matrix production, reducing its ability to colonize territorial space through competitive exclusion.

Structural assembly of the human Miro1/2 GTPases based on the crystal structure of the N-terminal GTPase domain

The paper reports the crystal structure of the human Miro1 N-terminal GTPase domain bound to GTP and models the assembly of the full-length soluble domain of Miro1/2.