Author

J. Osei-Owusu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Z. Qiu· 2 shared A. C. Kruse· 1 shared D. S. Marks· 1 shared D. S. Matasic· 1 shared J. A. Paulo· 1 shared J. Mintseris· 1 shared K. P. Brock· 1 shared L. Mihaljevic· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Z. Qiu

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Author profile →

3 papers

Recent·Most cited

Inhibition of the proton-activated chloride channel PAC by PIP2

L. Mihaljevic, R. Zheng, J. Osei-Owusu, W. Lü, Z. Qiu

This study identifies PIP2 as an inhibitor of the PAC channel, revealing its binding site and mechanism through structural and electrophysiological analyses.

bioRxiv · Oct 6, 2022Biochemistry

Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC

J. Osei-Owusu, Z. Ruan, D. S. Matasic, W. Lu, Z. Qiu

This study identifies key residues and structural interactions involved in pH-dependent desensitization of the proton-activated chloride (PAC) channel using electrophysiology, mutagenesis, and molecular dynamics simulations.

bioRxiv · Aug 30, 2022Biophysics

The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

S. C. Erlandson, S. Rawson, J. Osei-Owusu, K. P. Brock, X. Liu, J. A. Paulo, J. Mintseris, S. P. Gygi, D. S. Marks, X. Cong, A. C. Kruse

This study determines the cryo-EM structure of active-state RXFP1 bound to relaxin-2 and Gs protein, revealing an autoinhibition mechanism.

bioRxiv · Jan 22, 2022 · PreprintPharmacology & Toxicology