Author

S. C. Erlandson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

A. C. Kruse· 3 shared A. M. Ring· 1 shared A. Manglik· 1 shared A. S. Baier· 1 shared C. McMahon· 1 shared D. Hilger· 1 shared D. S. Marks· 1 shared H. A. Rockman· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPharmacology & Toxicology

A. C. Kruse

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3 papers

Recent·Most cited

Engineering and characterization of a long half-life relaxin receptor RXFP1 agonist

S. C. Erlandson, J. Wang, H. Jiang, H. A. Rockman, A. C. Kruse

This study engineers a relaxin-2 variant with a longer serum half-life by fusing it with an antibody Fc fragment, maintaining RXFP1 agonist activity in vitro and in vivo.

bioRxiv · Apr 19, 2022Pharmacology & Toxicology

The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

S. C. Erlandson, S. Rawson, J. Osei-Owusu, K. P. Brock, X. Liu, J. A. Paulo, J. Mintseris, S. P. Gygi, D. S. Marks, X. Cong, A. C. Kruse

This study determines the cryo-EM structure of active-state RXFP1 bound to relaxin-2 and Gs protein, revealing an autoinhibition mechanism.

bioRxiv · Jan 22, 2022 · PreprintPharmacology & Toxicology

Platform for rapid nanobody discovery in vitro

C. McMahon, A. S. Baier, S. Zheng, R. Pascolutti, J. X. Ong, S. C. Erlandson, D. Hilger, A. M. Ring, A. Manglik, A. C. Kruse

This paper presents an in vitro platform for rapid nanobody discovery using yeast surface display, demonstrating its application to various antigens including lipid flippase and G protein-coupled receptors.

bioRxiv · Jun 16, 2017Biochemistry