Author

K. P. Brock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

D. S. Marks· 3 shared D. Marks· 2 shared A. A. Cohen· 1 shared A. Alon· 1 shared A. C. Kruse· 1 shared A. C. Sherman· 1 shared A. Dauphin· 1 shared A. G. Green· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersPharmacology & Toxicology

D. S. Marks

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Author profile →

5 papers

Recent·Most cited

Protein design for evaluating vaccines against future viral variation

N. Youssef, S. Gurev, F. Ghantous, K. P. Brock, J. A. Jaimes, N. N. Thadani, A. Dauphin, A. C. Sherman, L. Yurkovetskiy, D. Soto, R. Estanboulieh, B. Kotzen, P. Notin, A. W. Kollasch, A. A. Cohen, , D. Marks

The paper designs SARS-CoV-2 Spike proteins with novel mutations to evaluate vaccine effectiveness against future viral variants using a deep learning model.

bioRxiv · Oct 8, 2023Immunology

The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

S. C. Erlandson, S. Rawson, J. Osei-Owusu, K. P. Brock, X. Liu, J. A. Paulo, J. Mintseris, S. P. Gygi, D. S. Marks, X. Cong, A. C. Kruse

This study determines the cryo-EM structure of active-state RXFP1 bound to relaxin-2 and Gs protein, revealing an autoinhibition mechanism.

bioRxiv · Jan 22, 2022 · PreprintPharmacology & Toxicology

Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

N. Akyuz, K. D. Karavitaki, B. Pan, P. I. Tamvakologos, K. P. Brock, Y. Li, D. S. Marks, D. P. Corey

The paper investigates how mutations in TM4 and TM6 helices of TMC1 affect mechanical gating of auditory transduction channels in hair cells.

bioRxiv · Dec 30, 2021Biophysics

Dormant spores sense amino acids through the B subunits of their germination receptors

L. Artzi, A. Alon, K. P. Brock, A. G. Green, A. Tam, F. H. Ramirez-Guadiana, D. Marks, A. Kruse, D. Z. Rudner

The paper identifies GerAB as the L-alanine sensor in spores, showing mutations in its ligand-binding pocket impair germination and substitutions enable response to other amino acids.

bioRxiv · Oct 28, 2021Microbiology

Protein structure from experimental evolution

M. A. Stiffler, F. J. Poelwijk, K. P. Brock, R. R. Stein, J. Teyra, S. S. Sidhu, D. S. Marks, N. P. Gauthier, C. Sander

This study uses laboratory evolution to infer protein structures by analyzing residue interactions from evolved sequences.

bioRxiv · Jun 13, 2019Evolutionary Biology