Author

J. P. Heiskanen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

A. Galera-Prat· 2 shared L. Lehtiö· 2 shared M. M. Maksimainen· 2 shared S. T. Sowa· 2 shared A. Fehr· 1 shared D. Cluff· 1 shared D. V. Ferraris· 1 shared E. Rolina· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

A. Galera-Prat

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Author profile →

2 papers

Recent·Most cited

Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target

S. Wazir, T. A. O. Parviainen, M. M. Maksimainen, M. T. H. Duong, J. J. Pfannenstiel, D. Cluff, S. T. Sowa, A. Galera-Prat, D. V. Ferraris, A. Fehr, J. P. Heiskanen, L. Lehtiö

This paper identifies small molecule inhibitors of SARS-CoV-2 Mac1 that inhibit coronavirus replication, validating Mac1 as an anti-viral target.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs

M. M. Maksimainen, S. Murthy, S. T. Sowa, A. Galera-Prat, E. Rolina, J. P. Heiskanen, L. Lehtiö

The paper develops TIQ-A analogs that selectively inhibit mono-ADP-ribosyltransferases PARP10 and PARP15 over poly-ADP-ribosyltransferases, achieving 10-20-fold selectivity while maintaining micromolar potency.

bioRxiv · Aug 30, 2021Biochemistry