J. P. O'Gara

This study shows that mutating the pentose phosphate pathway gene pgl in MRSA increases resistance to beta-lactam antibiotics through metabolic reprogramming and changes in cell envelope precursors.

This study shows that purine nucleosides like guanosine and xanthosine reduce β-lactam resistance in MRSA by lowering c-di-AMP levels, acting as adjuvants to restore antibiotic effectiveness.

This study shows that mutating lspA or inhibiting LspA with globomycin increases MRSA resistance to beta-lactam antibiotics by affecting cell envelope components beyond peptidoglycan.

The paper shows that impairing alanine transport or exposing MRSA to D-cycloserine increases susceptibility to beta-lactam antibiotics by reducing peptidoglycan crosslinking.