Author

M. S. Zeden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:bacteria (other)· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. P. O'Gara· 3 shared A. Grundling· 2 shared A. Nolan· 2 shared C. F. Schuster· 2 shared E. Bueno· 2 shared F. Cava· 2 shared I. Kviatkovski· 2 shared P. D. Fey· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. P. O'Gara

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

M. S. Zeden, L. A. Gallagher, E. Bueno, A. Nolan, J. Ahm, D. Shinde, F. Razvi, M. Sladek, O. Burke, E. O'Neill, P. D. Fey, F. Cava, V. C. Thomas, J. P. O'Gara

This study shows that mutating the pentose phosphate pathway gene pgl in MRSA increases resistance to beta-lactam antibiotics through metabolic reprogramming and changes in cell envelope precursors.

bioRxiv · Mar 3, 2023 · PreprintMicrobiology

Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics

A. Nolan, M. S. Zeden, C. Campbell, I. Kviatkovski, L. Urwin, R. M. Corrigan, A. Gründling, J. P. O'Gara

This study shows that purine nucleosides like guanosine and xanthosine reduce β-lactam resistance in MRSA by lowering c-di-AMP levels, acting as adjuvants to restore antibiotic effectiveness.

bioRxiv · Sep 1, 2022 · PreprintMicrobiology

Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to beta-lactam antibiotics

C. Fingleton, M. S. Zeden, E. Bueno, F. Cava, J. P. O'Gara

This study shows that mutating lspA or inhibiting LspA with globomycin increases MRSA resistance to beta-lactam antibiotics by affecting cell envelope components beyond peptidoglycan.

bioRxiv · Feb 3, 2021 · PreprintMicrobiology

Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c-di-AMP production

M. S. Zeden, I. Kviatkovski, C. F. Schuster, V. C. Thomas, P. D. Fey, A. Grundling

This study identifies glutamine and glutamate transporters in S. aureus and shows their impact on c-di-AMP production and growth in rich medium.

bioRxiv · Dec 17, 2019Microbiology

Cyclic-di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions

M. S. Zeden, C. F. Schuster, L. Bowman, Q. Zhong, H. D. Williams, A. Grundling

This study identifies c-di-AMP's role in osmotic regulation in S. aureus but shows it is not required for anaerobic growth.

bioRxiv · Jan 5, 2018Microbiology