Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer's disease
A. Guyon, J. Rousseau, F. Gabriel Begin, T. Bertin, G. Lamothe, J. P. Tremblay
The paper inserts the A673T mutation in the APP gene using base editing to reduce β-secretase cleavage and potentially prevent Alzheimer's disease progression.
bioRxiv · Oct 27, 2020Bioengineering