C. Beausejour

Senescent human fibroblasts have increased FasL expression and impair the tumor immune response

The paper shows senescent human fibroblasts increase FasL expression, leading to T and NK cell apoptosis and impaired tumor immune response in humanized models.

Nuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes

This study identifies nuclear localization of HCAR1 as a driver of cancer malignancy through multiple mechanisms including nuclear signaling and transcriptomic regulation.

Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1.

This study identifies a senescent molecular signature in DM1 myogenic cells and shows that senolytics reduce SASP and restore myogenesis.

Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

This paper develops autologous humanized mouse models of iPSC-derived tumors to study and modulate cancer-immune interactions, showing immune infiltration and response to PD-1 inhibition.

NK cells prevent the formation of teratomas derived from human induced pluripotent stem cells

This study shows that NK cells prevent teratoma formation from hiPSCs in immune competent hosts, while autologous T cells can reject established teratomas.

Immune tolerance of human induced pluripotent stem cell-derived myogenic progenitor cells in humanized mice

This study evaluates immune tolerance of hiPSC-derived myogenic progenitor cells in humanized mice, finding autologous cells are tolerated while allogeneic grafts are rejected, and NK cell transfer prevents teratoma formation.

The tumor immune response is not compromised by mesenchymal stromal cells in humanized mice

This study shows that human umbilical cord mesenchymal stromal cells do not affect tumor growth or immune rejection in humanized mice.

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.