Author

J. Petrini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Henssen· 1 shared A. J. Matthews· 1 shared A. Kentsis· 1 shared A. Kung· 1 shared A. V. Penson· 1 shared B. S. Taylor· 1 shared C. Reed· 1 shared E. de Stanchina· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

A. Henssen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Structure-Selective Endonucleases GEN1 and MUS81 are Functionally Complementary in Safeguarding the Genome of Proliferating B Lymphocytes

K. C. Fernandez, L. Feeney, R. M. Smolkin, A. J. Matthews, W.-F. Yen, J. Chaudhuri, J. Petrini

This study shows that GEN1 and MUS81 are essential for B lymphocyte development and genome stability by resolving DNA recombination intermediates.

bioRxiv · Feb 9, 2022Immunology

Nbs1 Mediates Assembly and Activity of the Mre11 complex

J. H. Kim, A. V. Penson, B. S. Taylor, J. Petrini

This study shows that Nbs1mid8 mutant mice develop T cell leukemias with mutations similar to human T-ALL, suggesting Nbs1's role in Mre11 complex assembly and activity.

bioRxiv · Mar 13, 2019 · PreprintCancer Biology

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

A. Henssen, C. Reed, E. Jiang, H. D. Garcia, J. von Stebut, I. MacArthur, P. Hundsdoerfer, J. Hyun Kim, E. de Stanchina, Y. Kuwahara, H. Hosoi, N. Ganem, F. Dela Cruz, A. Kung, J. Schulte, , A. Kentsis

This study identifies PGBD5 as a therapeutic target in pediatric solid tumors, showing that inhibiting DNA repair pathways with AZD6738 sensitizes these tumors to apoptosis.

bioRxiv · Aug 25, 2017Cancer Biology