Author

J. von Stebut

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

A. Eggert· 2 shared A. G. Henssen· 2 shared A. M. Wengner· 2 shared F. F. Pusch· 2 shared G. Seifert· 2 shared H. Dorado Garcia· 2 shared J. H. Schulte· 2 shared K. Haase· 2 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Eggert

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Elimusertib outperforms standard of care chemotherapy in preclinical patient-derived pediatric solid tumor models

F. F. Pusch, H. Dorado Garcia, R. Xu, D. Gürgen, Y. Bei, L. Brückner, C. Röefzaad, J. von Stebut, V. Bardinet, M. d. R. Chamorro Gonzalez, A. Eggert, J. H. Schulte, P. Hundsdörfer, G. Seifert, K. Haase, , A. G. Henssen

This paper evaluates elimusertib's preclinical efficacy in pediatric solid tumor models, finding it outperforms standard chemotherapy, especially in alveolar rhabdomysarcoma.

bioRxiv · Nov 10, 2022 · PreprintCancer Biology

Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy

H. Dorado Garcia, Y. Bei, J. von Stebut, G. Ibanez, K. Imami, D. Gurgen, J. Rolff, K. Helmsauer, N. Timme, V. Bardinet, R. Chamorro Gonzalez, I. C. MacArthur, F. F. Pusch, C. Y. Chen, J. Schulz, , A. G. Henssen

This study identifies ATR as a synthetic lethal target in PAX3-FOXO1-driven rhabdomyosarcoma, showing ATR inhibition enhances PARP inhibitor efficacy and is tolerated in patients.

bioRxiv · Dec 4, 2020 · PreprintCancer Biology

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

A. Henssen, C. Reed, E. Jiang, H. D. Garcia, J. von Stebut, I. MacArthur, P. Hundsdoerfer, J. Hyun Kim, E. de Stanchina, Y. Kuwahara, H. Hosoi, N. Ganem, F. Dela Cruz, A. Kung, J. Schulte, , A. Kentsis

This study identifies PGBD5 as a therapeutic target in pediatric solid tumors, showing that inhibiting DNA repair pathways with AZD6738 sensitizes these tumors to apoptosis.

bioRxiv · Aug 25, 2017Cancer Biology