Author

J. Piton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. T. Cole· 2 shared A. Lupien· 1 shared A. Vocat· 1 shared C. S.-Y. Foo· 1 shared C. Sala· 1 shared M. Zhang· 1 shared O. Riabova· 1 shared P. Soler-Arnedo· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

S. T. Cole

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2 papers

Recent·Most cited

Polarly localized EccE1is required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis

P. Soler-Arnedo, C. Sala, M. Zhang, S. T. Cole, J. Piton

This study identifies EccE1 as a critical membrane protein required for ESX-1 function and stabilization of ESX-1 membrane proteins in Mycobacterium tuberculosis, with deletion of eccE1 reducing levels of other ESX-1 components and attenuating bacterial virulence.

bioRxiv · Oct 30, 2019Microbiology

Structure-based drug design and characterization of sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from Mycobacterium tuberculosis

J. Piton, A. Vocat, A. Lupien, C. S.-Y. Foo, O. Riabova, V. Makarov, S. T. Cole

The paper designs and characterizes sulfonyl-piperazine benzothiazinone inhibitors of DprE1 from M. tuberculosis, finding they have improved solubility but lower activity than MCZ.

bioRxiv · Apr 10, 2018Pharmacology & Toxicology