Author

J. R. Connor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Lathia· 3 shared D. J. Silver· 2 shared K. Palsa· 2 shared A. Sheikhi· 1 shared B. Slagle-Webb· 1 shared B. W. Kristensen· 1 shared C. G. Hubert· 1 shared C. Khunsriraksakul· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

J. Lathia

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Author profile →

4 papers

Recent·Most cited

Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier

S. L. Baringer, K. Palsa, I. A. Simpson, J. R. Connor

This study shows apo- and holo-transferrin differentially regulate iron release at the blood-brain barrier by interacting with ferroportin and hephaestin, with hepcidin modulating these interactions.

bioRxiv · Jan 10, 2023Cell Biology

Iron Inhibits Glioblastoma Cell Migration and Polarization

G. Shenoy, S. Kheirabadi, Z. Ataie, K. Palsa, Q. Wade, C. Khunsriraksakul, V. Khristov, B. Slagle-Webb, J. Lathia, H.-G. Wang, A. Sheikhi, J. R. Connor

This study shows that increasing cellular iron content reduces migratory capacity and polarization in human glioblastoma cells, with CDC42 expression being affected.

bioRxiv · Oct 13, 2022Cancer Biology

Tumor cell-intrinsic HFE drives glioblastoma growth

K. M. Troike, D. J. Silver, P. K. Ghosh, E. E. Mulkearns-Hubert, C. G. Hubert, J. R. Connor, P. L. Fox, B. W. Kristensen, J. Lathia

This study shows that HFE promotes glioblastoma growth by regulating iron homeostasis and oxidative stress, with HFE loss inducing apoptosis and extending survival.

bioRxiv · Apr 13, 2022 · PreprintCancer Biology

JAM-A functions as a female microglial tumor suppressor in glioblastoma

S. M. Turaga, D. J. Silver, D. Bayik, E. Paouri, S. Peng, N. Borjini, S. Stanko, U. Naik, R. A. Keri, J. R. Connor, J. Barnholtz-Sloan, J. B. Rubin, M. Berens, D. Davalos, J. Lathia

This study shows that JAM-A deficiency in female mice increases microglia activation and GBM growth, revealing a sex-specific role for JAM-A in the tumor microenvironment.

bioRxiv · Sep 11, 2019Cancer Biology