Author

J. R. Foley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:Drosophila· 1 Organism:mouse· 1

Frequent Co-Authors

R. A. Casero· 3 shared T. R. Murray Stewart· 2 shared A. R. Khomutov· 1 shared A. Toker· 1 shared A. Yassin-Kassab· 1 shared C. E. Holbert· 1 shared J. M. Asara· 1 shared M. A. Khomutov· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

R. A. Casero

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Polyamine transport inhibition and cisplatin synergistically enhance tumor control through oxidative stress in murine head and neck cancer models

A. Yassin-Kassab, N. Wang, J. R. Foley, T. R. Murray Stewart, M. R. Burns, R. A. Casero, R. A. Harbison, U. Duvvuri

This study shows that combining cisplatin with AMXT-1501 enhances tumor control in HNSCC models by increasing oxidative stress and apoptosis, independent of polyamine levels.

bioRxiv · Jul 25, 2023Cancer Biology

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential

T. R. M. Stewart, J. R. Foley, C. E. Holbert, M. A. Khomutov, N. Rastkari, X. Tao, A. R. Khomutov, R. G. Zhai, R. A. Casero

This study shows DFMO rebalances polyamine ratios in SRS patient cells and extends lifespan in a Drosophila model, suggesting therapeutic potential for SRS.

bioRxiv · Mar 30, 2023Biochemistry

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

R. C. Geck, J. R. Foley, T. R. Murray Stewart, J. M. Asara, R. A. Casero, A. Toker

This study shows that inhibiting ODC with DFMO sensitizes TNBC cells to chemotherapy, but not receptor-positive breast cancer cells.

bioRxiv · Jan 8, 2020Cancer Biology